clair073

When you remember first meeting the love of your life, do you also have a strong memory of where you both were and also where you were in relation to objects in the scene? When I first met my wife, Doris, it was at a party and she was at a piano surround by “bird dog” males, who I saw from an adjacent room. In my mind’s eye, I still see both rooms and where everybody was. Do you remember where you were on 9/11? I was in the waiting room of a hospital, looking over a series of lounge chairs at a large-screen TV program that was reporting the news. It seems that many people remember not only events but where they were at the time of the event. But how does this happen? We do know that a new experience may be “consolidated” into a lasting memory, especially if it stirs emotion and you replay it in your mind. That is certainly the case when you meet the love of your life or see a terrible event. If you were there, you would surely remember what you were doing. Back in the 1970s I was study...

If we learn anything about educational policy, we should learn that what we have tried over the last couple of decades to improve student achievement doesn’t work very well. I won’t bore you with all the statistics showing that academic ability of U.S. students lags that of most other developed countries and our ranking is not improving. I would like to explore one reason for lack of progress besides faulty federal policy. And that reason is research funding. We don’t know enough about how brains learn and remember, nor how to apply what we do know to educational policy. The recently announced winners of the Nobel Prize included nine from the U.S. In a recent joint interview by leaders of the American Association of Science, the winners spent little time discussing their research achievements, preferring to expound on some serious concerns about how research is now funded in the U.S. Of course, some of these concerns could be considered whining. Like much of the general public, the sci...

When I was in veterinary medical school, I could often be found lounging in the fraternity living room listening to jazz records. My classmates were stunned that I was wasting so much time, when most of them had to study while I seemingly had nothing to do. O.K., so maybe I graduated fifth in my class rather than first, but I was not nearly as stressed as my classmates. My reason for sacrificing study time was that it bolstered my spirits. Veterinary medicine is a lot harder than most people think. Veterinarians learn the same anatomy, physiology, pharmacology, microbiology, and so on as physicians do. In some schools, human and veterinary medical students take many of the same basic science classes. Moreover, veterinary students have to learn about multiple species, learn more public health, and take a year’s worth of surgery. But back to the music issue: some people, especially students, think that listening to music helps the memory. Historically, supporters of this practice have re...

It’s normal to get depressed. Let’s face it, a lot of life experience IS depressing. Depression that is severe enough to be considered a clinical malady is a state that persists for long periods. It’s not the initial depression that is the problem, but rather its sustained nature. So, the issue is what sustains the depression. I contend that continual rehearsal of negative emotions, which can be done explicitly or implicitly, is the driver of clinical depression. I don’t know if psychologists agree or not, but as a neuroscientist I know that rehearsal of thoughts and feelings strengthens the mediating synapses and circuits. Obviously, consciously rehearsing bad events and our depressive response will help to cement depression in neural circuitry. But even implicit rehearsal can have the same effect. This being the case, it seems important to focus on the triggers that activate recall, explicit or implicit, of stored representations of depressed feelings. Bad events and their associated...

The more a woman weighs, the worse her memory. No, I am not a chauvinist pig. This claim comes from actual research—by a woman, no less. Diana Kerwin and her colleagues at Northwestern University studied 8,745 women ages 65 to 79 and found that for every one-point increase in female body mass index, the score on a 100 point memory test dropped by one point. The problem was greatest in women who had put the weight on around the hips, which is fairly typical for weight gain in women. Nobody knows why this is so. Fat deposits may increase the amount of cytokines, which are hormones that can cause inflammation. In a couple of earlier columns I explained how body inflammation, from sore joints or sore throat, for example, can trigger inflammation in the brain. I explained that brains can get inflamed too, irritated from the release of cytokines and other toxins from the brain’s immune cells in response to inflammation. In both genders, these toxins diminish mental capabilities, especially m...

In 1913, Ebbinghaus demonstrated that spacing learning out over time creates much more efficient learning than cramming a learning task into a single intense session. Now, a new discovery has been made for a specific spaced-learning strategy that so far is the best of all. In reviewing this new design, Kelley and Whatson (2013) point out experiments showing that this kind of spaced learning is optimal for information encoding and for activation of the genes needed to form long-term memory. And what is the design? The idea begins with the established notion that a given learning task should be “chunked” so that it can be studied in a short time, on the order say of 20 minutes. What is novel about the new design is that a given chunk is studied three times in a single session, with two intervening “rest” periods of 10 minutes in which there is little mental activity. During the rest periods, physical activity, like shooting hoops or cycling, seem to be ideal. The reason for these interve...

“Life, liberty, and the pursuit of happiness:” some people might argue that the U.S. Constitution endorses hedonism, and indeed many politicians want to ignore or get rid of the Constitution, but not necessarily because of hedonism. We should not be dismissive about encouraging people to pursue happiness. Happiness can be good for your brain. Depression is surely bad for your brain. Positive mood states promote more effective thinking and problem solving. A recent scholarly report [1] reviews the literature demonstrating that positive mood broadens the scope of attentiveness, enhances semantic associations over a wide range, improves task shifting, and improves problem-solving capability. The review also documents the changes in brain activation patterns induced by positive mood in subjects while solving problems. Especially important is the dopamine signaling in the prefrontal cortex. Published studies reveal that a variety of techniques are used to momentarily manipulate mood. These ...