Aging Shrinks the Brain
In most people, their brains get smaller as they age. It is not so much that neurons die but that their terminals and synaptic junctions shrivel. A known cause is the over-secretion of cortisol by stress, but perhaps there are also other age-related causes. However, shrinkage with age is not inevitable. Certain people are "super-agers," defined as adults over 80 with memory at least as good as normal middle-aged adults. A usually reliable index for decline in memory ability is the degree of brain shrinkage, specifically cortical volume. Brain-scan studies show that super-agers have thicker layers of cortex than do others of the same age. Thus, their cortex has not shrunk as much as average elderly or they had more to start with. It is possible that something about the lifestyle of super-agers protected them from brain atrophy. It is not convenient to know how much cortical volume the elderly had in their youth. But the second option has been tested in a study that compared th...